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The leading edge of medicines and guidelines your doctor uses

Welcome to The Essential Guide to Medical News, I’m Dr. Jim Rybacki. This Channel will bring you the latest on emerging true breakthrough medicines, new FDA approvals and even new drug interactions that you should avoid. Many times, your doctor relies on guidelines from national organizations to steer prescribing based on the latest strong publications and I’m gonna tell you what they are and where to find them across the top 20 most common US disease and conditions! Timely, protective and easy to understand— this channel will tell you where we are now, what we have and what the future most likely will bring via timely articles, eBooks and videos too! I’m Dr. Jim Rybacki for the Essential Guide to Prescription Welcome! 

BREAKTHROUGH Medicine FDA approved 9/11/23

Aphexdra (motixafortide) has been approved by the FDA and is the FIRST innovation in ten years for multiple myeloma patients. This novel medicine is to be used in combination with Filgrastim (G-CSF) to mobilize crucial Stem Cells for collection and Subsequent patient transplant (Autologous) in people with Multiple Myeloma.

Multiple myeloma (MM) is a cancer of the blood that does NOT have a cure. This incurable cancer affects a crucial kind of white blood cell called a plasma cell in the bone marrow. In MM patients, these abnormal plasma cells spread and replace normal cells and this diagnosis happens in more than 35,000 in the US. Nearly 13,000 patients die from MM each year.

Aphexdra (motixafortide) is expected to become the new standard of care in myeloma patients who are going to get a bone marrow transplant (Autologous Stem Cell Therapy or ASCT). It will be used in combination with an older medicine called filgrastim (G-CSF) to help make certain that the required number of cells can be mobilized (3-5 X 106 CD34+ cells/kg2) to be successful.

Remarkably, this medicine is expected to actually be available to help patients in late September 2023. The company plans a conference call September 12, 2023 and already has a video press release detailing the medicine further at

More to follow as always on this True Breakthrough with a detailed video on Channel two of this site by September 21, 2023.

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